Disease Landscape
Patients with low-risk prostate cancer often receive unnecessary radical therapy.
Current guidelines recommend that patients with low-risk prostate cancer pursue either active surveillance or radical therapy.1
Active Surveillance
Although active surveillance is currently the preferred management option for patients with low-risk prostate cancer, many eventually transition to radical therapy.1-4
Many patients will eventually transition to radical therapy.5-6
Radical Therapy
Prostatectomy and radiation carry risks of negative side effects and lasting complications.7
There remains a clinical unmet need to balance active surveillance with intervention for patients with low-risk prostate cancer.
References:
1. Eastham JA, et al. J Urol. 2022;208(1):10–18. 2. Kirk PS, et al. Cancer. 2022;128(2):269–274. 3. Venderbos LDF, et al. Psychooncology. 2015;24(3):348–354. 4. McIntosh M, et al. Psychooncology. 2022;31(8):1420–1430. 5. Hamdy FC, et al. N Engl J Med. 2023;388:1547–1558. 6. Palmstedt E, et al. Eur Urol. 2025.2025;88(4):373–380. 7. Unger JM, et al. JAMA Oncol. 2024; 10(12):1654–1662. 8. Cooperberg MR, et al. JAMA. 2023;6(3):e231439. 9. Hayes JH, et al. JAMA. 2010; 304(21): 2373–2380. 10. Cooley LF, et al. J Urol. 2021; 206(5):1147–1156.